tag:blogger.com,1999:blog-35656281923030695792024-03-15T18:09:31.627-07:00Pharma SkeletonsPharma Skeletonshttp://www.blogger.com/profile/01448776535058222749noreply@blogger.comBlogger3125tag:blogger.com,1999:blog-3565628192303069579.post-73705719181579509832022-07-14T08:29:00.001-07:002022-07-14T08:29:56.093-07:00Return of the King<p> </p><div class="separator" style="clear: both; text-align: center;"><div class="separator" style="clear: both; text-align: center;"><a href="https://blogger.googleusercontent.com/img/a/AVvXsEjmRJEKgWNFSRgmp5tNL3SCMec_XEW6Poz9-JosggY9HS0c1ffGJavVcMSu53KN1NG3HX-sD2v52S2l_88YKyX1YfnkyRov4bMuEPBw647IMgSI2syKMSkkZkvR-T8PjjPkl1DkVuk9si-u3RmhHnNX3f3vjspUZ013rbgzuoGTKzNy5tnQWmJKcpNB" style="margin-left: 1em; margin-right: 1em;"><img alt="" data-original-height="212" data-original-width="184" height="240" src="https://blogger.googleusercontent.com/img/a/AVvXsEjmRJEKgWNFSRgmp5tNL3SCMec_XEW6Poz9-JosggY9HS0c1ffGJavVcMSu53KN1NG3HX-sD2v52S2l_88YKyX1YfnkyRov4bMuEPBw647IMgSI2syKMSkkZkvR-T8PjjPkl1DkVuk9si-u3RmhHnNX3f3vjspUZ013rbgzuoGTKzNy5tnQWmJKcpNB" width="208" /></a></div><br /><br /></div><br /><p></p>Pharma Skeletonshttp://www.blogger.com/profile/01448776535058222749noreply@blogger.com7tag:blogger.com,1999:blog-3565628192303069579.post-80280717509450274502018-04-01T00:00:00.000-07:002018-04-01T09:44:21.171-07:00Big Pharma Skeletons In The Closet by Martin Shkreli<div style="background-color: white; color: #666666; font-family: "Trebuchet MS", Trebuchet, Verdana, sans-serif; font-size: 13.2px; text-align: center;">
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Below was written by Martin Shkreli in January 2017:</div>
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Welcome to Pharma Skeletons,<span style="font-size: large;"><b> by Martin Shkreli</b></span></div>
<span style="background-color: white; color: #666666; font-family: "trebuchet ms" , "trebuchet" , "verdana" , sans-serif; font-size: 13.2px;">Stephen Ubl, </span><br />
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<span style="background-color: white; color: #666666; font-family: "trebuchet ms" , "trebuchet" , "verdana" , sans-serif; font-size: 13.2px;">Don't you dare point your finger at me for the pharmaceutical industry's troubles. It turns out we've all made some unpopular moves.</span><br />
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Abbvie/Abbott</div>
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<span style="color: #888888;"><a href="http://www.natap.org/2004/jan/011504_13.htm"><span id="goog_1615275672"></span>Abbott raised the price of an HIV drug, Norvir, (sound familiar?) to huge public outcry.</a></span></div>
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<a href="http://www.natap.org/2003/dec/123103_2.htm"><span id="goog_1615275673"></span>People were pissed.</a></div>
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<a href="https://www.sec.gov/Archives/edgar/data/1800/000104746905005185/a2149332z10-k.htm#toc_fc4662_1" style="color: #888888; text-decoration-line: none;">They didn't need to. Abbott had billions of dollars of net income that year.</a></div>
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Abbott still raises the price of Humira, every year. This is despite Humira being the best selling drug on the planet.</div>
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Allergan</div>
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Allergan pretends 10% price increases make sense in a no-inflation environment. Just assume no one can do math. A big price increase on a small product is worse than small increases on big products, right?</div>
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<a href="https://www.sec.gov/news/pressrelease/2017-16.html" style="color: #888888; text-decoration-line: none;">Just paid the SEC a ton of cash to settle allegations it wasn't disclosing M&A events properly.</a></div>
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<a href="https://www.nytimes.com/2014/09/16/business/new-york-files-antitrust-suit-against-maker-of-alzheimers-drug.html?_r=0" style="color: #888888; text-decoration-line: none;">We pulled Namenda IR off the market so that we could greedily switch patients to Namenda XR.</a></div>
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But everyone else is the bad actor, not us.</div>
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Don't forget the inversion to avoid taxes, as well as their attempt to reverse merge with Pfizer to take them out of the U.S. tax system as well.</div>
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Remember that this is the company that does not do any R&D -- they buy-in and call that "open science". Open bullshit.</div>
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Amgen</div>
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<a href="http://www.reuters.com/article/us-usa-healthcare-drugpricing-idUSKCN0X10TH" style="color: #888888; text-decoration-line: none;">No price increases here! No scientists either! Just lawyers.</a></div>
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<a href="http://www.nytimes.com/2007/03/10/washington/10fda.html" style="color: #888888; text-decoration-line: none;">Company was accused of pushing EPO so hard that it became toxic to patients. Remember that?</a></div>
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The company hasn't had a science-oriented CEO in decades. Their R&D productivity is pathetic.</div>
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Avanir</div>
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We sell... cough syrup? We got a patent on the cough syrup for pseudobulbar affect. Somehow it got FDA approved.</div>
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It's not a big selling drug or anything, but we need lobbying.</div>
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Bayer</div>
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We raise prices on drugs by 100%+ but no one notices.</div>
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<a href="http://www.nytimes.com/2003/02/22/business/papers-indicate-that-bayer-knew-of-dangers-of-its-cholesterol-drug.html" style="color: #888888; text-decoration-line: none;">'Member Baycol? Oh, I member.</a></div>
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Biogen</div>
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<a href="http://www.wsj.com/articles/for-prescription-drug-makers-price-increases-drive-revenue-1444096750" style="color: #888888; text-decoration-line: none;">Price increases power this shitty business.</a></div>
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Tecfidera was a cheap drug available overseas.</div>
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New drug costs $750,000 its first year and ~$300,000 every year thereafter. Daraprim is $25,000 one time. Get mad!</div>
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Biogen doesn't fool anyone into thinking they're "innovative".</div>
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Biomarin</div>
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Kuvan doesn't cost much in Europe.</div>
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Bristol-Myers</div>
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<a href="https://www.justice.gov/archive/atr/public/press_releases/2008/232525.htm" style="color: #888888; text-decoration-line: none;">Is anyone old enough to 'member old Bristol Myers? Vanlev? Richard Lane? Peter Dolan? I 'member.</a></div>
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It sure is easy to pretend you're a model citizen when your company went through a pretty ugly period fifteen years ago.</div>
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Celgene</div>
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<a href="http://www.wsj.com/articles/SB110047032850873523" style="color: #888888; text-decoration-line: none;">So we took a really old drug, price increased that by a lot.</a></div>
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<a href="http://www.wsj.com/articles/SB115170926747095892" style="color: #888888; text-decoration-line: none;">Then we made PRODRUGS of that drug and priced them even higher.</a></div>
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<a href="http://www.investorvillage.com/smbd.asp?mb=341&mn=198446&pt=msg&mid=15057695" style="color: #888888; text-decoration-line: none;">THEN we increased the prodrug EVEN MORE.</a></div>
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Eli Lilly</div>
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<a href="https://www.washingtonpost.com/news/wonk/wp/2016/12/13/after-years-of-price-hikes-eli-lilly-announces-a-discount-on-insulin/?utm_term=.852bf729d0e1" style="color: #888888; text-decoration-line: none;">No price increases to speak of. Model citizen.</a></div>
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<a href="http://www.wsj.com/articles/drugmakers-find-competition-doesnt-keep-a-lid-on-prices-1480248003" style="color: #888888; text-decoration-line: none;">Except Cialis which mysteriously has the same price changes as Viagra.</a></div>
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Esperion</div>
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<a href="http://www.esperion.com/development/" style="color: #888888; text-decoration-line: none;">We don't even sell drugs yet but we spend shareholder money on lobbying.</a></div>
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Genentech</div>
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<a href="http://www.nytimes.com/1988/01/05/business/fast-start-for-bioengineered-drug.html?pagewanted=all" style="color: #888888; text-decoration-line: none;">Andy Pollack wrote a story in the New York Times in 1988 complaining about the high price of Activase.</a></div>
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Some things never change.</div>
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With that said, Genentech is an awesome science-driven company who had a card-carrying scientist CEO.</div>
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<a href="http://www.nytimes.com/1990/11/21/business/wife-of-genentech-chief-fined-on-insider-trading.html" style="color: #888888; text-decoration-line: none;">But you should also look into the history of the guy who was there before Dr. Levinson.</a></div>
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<a href="http://articles.latimes.com/1995-07-11/business/fi-22747_1_g-kirk-raab" style="color: #888888; text-decoration-line: none;">Man, what a scumbag.</a></div>
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GSK</div>
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Do we even do pharma anymore? Consumer head now runs our business.</div>
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We sold off our crappy old drugs to "price gougers".</div>
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Horizon</div>
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LOLOLOLOLOLOLOL. Deep breath. Resume laughing. LOLOLOLOLOL.</div>
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<a href="https://www.bloomberg.com/news/articles/2016-11-02/buy-and-flip-booms-in-drugs-market-as-private-equity-moves-in" style="color: #888888; text-decoration-line: none;">PHRMA is defending the poster child of price increases?</a></div>
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Doing a Freidreich's study that couldn't have worked doesn't count as R&D that will magically absolve you.</div>
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Horizon is another tax avoider. Ireland headquarters. So much pharma talent there.</div>
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Jazz</div>
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This is a really smart shareholder-focused company. But if you are looking for the vanguard of R&D, keep looking.</div>
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Jazz is another "Dublin" headquartered company.</div>
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Johnson & Johnson</div>
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J&J has had a very hard time making their OTC medicines.</div>
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Writing about J&J transgressions will take some time.</div>
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Lundbeck</div>
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Because when your patent is expiring: TRY THE ISOMER!</div>
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Mallinckrodt</div>
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Really? Acthar's 65,000% price increase represents your values but Turing doesn't?</div>
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Gosh, I'm so upset my portfolio companies aren't a part of your trade group.</div>
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Tax avoider? Check. Ireland.</div>
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Marathon</div>
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Bro. These guys invented price increases. I literally learned it from them.</div>
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<a href="http://www.fiercepharma.com/pharma/ovation-s-drug-price-hike-leads-to-lawsuit" style="color: #888888; text-decoration-line: none;">Ovation. I can start a new company, too.</a></div>
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Merck</div>
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<a href="http://www.npr.org/templates/story/story.php?storyId=5470430" style="color: #888888; text-decoration-line: none;">There was once a drug called Vioxx. I member Vioxx.</a></div>
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CEO is a lawyer. He was in senior management during the Vioxx scandal and was promoted.</div>
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Schering-Plough consent decree was an interesting time.</div>
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Novartis</div>
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Maybe the one honest, well-run company in pharma?</div>
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Novo Nordisk</div>
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Some price increases here if you look hard enough. Like, if you look at all.</div>
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Orexigen</div>
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<a href="https://www.sec.gov/Archives/edgar/data/1382911/000156459016027775/orex-10q_20160930.htm" style="color: #888888; text-decoration-line: none;">This company is barely solvent. Come on, what are you lobbying for?</a></div>
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I suggest they spend less money on dues and try to get profitable.</div>
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Pfizer</div>
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They raise price sometimes.</div>
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One of the most unproductive R&D groups in the history of pharmaceuticals.</div>
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"Pfizer fined $106 million fine for imposing a 2600% price hike"</div>
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Purdue</div>
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I know absolutely no one who blames this company for the opioid epidemic.</div>
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I doubt they even promote OxyContin.</div>
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Sanofi</div>
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Couple of price increases here, I think.</div>
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<span style="background-color: white; color: #666666; font-family: "trebuchet ms" , "trebuchet" , "verdana" , sans-serif; font-size: 13.2px;">Just a reminder.</span><br />
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You: Washington Lobbyist piece of shit.</div>
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Me: A guy who has done R&D and started two drug companies. When you learn what a nitrogen atom is, you can talk about me.</div>
<span style="background-color: white; color: #666666; font-family: "trebuchet ms" , "trebuchet" , "verdana" , sans-serif; font-size: 13.2px;">USPTO 8673883</span><br />
<span style="background-color: white; color: #666666; font-family: "trebuchet ms" , "trebuchet" , "verdana" , sans-serif; font-size: 13.2px;">USPTO 9181286</span><br />
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<span style="background-color: white; color: #666666; font-family: "trebuchet ms" , "trebuchet" , "verdana" , sans-serif; font-size: 13.2px;">Turing is a small company researching drugs for rare diseases that no one else wants to. All of your member companies, with a few humorous exceptions, have billions of dollars and don't need price increases. I'm sorry if my company's and patients' survival is inconvenient to your gigantic income streams.</span><br />
<span style="background-color: white; color: #666666; font-family: "trebuchet ms" , "trebuchet" , "verdana" , sans-serif; font-size: 13.2px;">Look in the mirror. This website took me half an hour to make, just 'membering a few moments from the past. Pharma is a wonderful industry that does great things, but trying to throw me under the bus is foolish. Let me remind you 90% of your members' CEOs could not hold a candle to me in scientific knowledge, achievements or wealth and entrepreneurial achievements.</span><br />
<span style="background-color: white; color: #666666; font-family: "trebuchet ms" , "trebuchet" , "verdana" , sans-serif; font-size: 13.2px;">90% of you are the same as you, Mr. Ubl, slick guys in suits who make a living spewing bullshit. Also keep in mind that I took a very low or zero salary at all of my companies. Your CEOs enjoy the fat paychecks they receive from price increases. I put my money from price increases into research. Half of big pharma CEOs could not tell you the first thing about science. </span><span style="background-color: yellow; color: #666666; font-family: "trebuchet ms" , "trebuchet" , "verdana" , sans-serif; font-size: 13.2px;">Maybe focus on changing that before you point at me and make false statements.</span><br />
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<span style="background-color: white; color: #666666; font-family: "trebuchet ms" , "trebuchet" , "verdana" , sans-serif; font-size: 13.2px;">Martin Shkreli</span><br />
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<span style="background-color: white; color: #666666; font-family: "trebuchet ms" , "trebuchet" , "verdana" , sans-serif; font-size: 13.2px;">Founder of Turing Pharmaceuticals AG</span><br />
<span style="background-color: white; color: #666666; font-family: "trebuchet ms" , "trebuchet" , "verdana" , sans-serif; font-size: 13.2px;">Founder of Retrophin, Inc.</span><br />
<span style="background-color: white; color: #666666; font-family: "trebuchet ms" , "trebuchet" , "verdana" , sans-serif; font-size: 13.2px;">Co-Inventor of a new series of pantothenate analogs for the treatment of pantothenate kinase associated neurodegeneration, a lethal pediatric illness</span><br />
<span style="background-color: white; color: #666666; font-family: "trebuchet ms" , "trebuchet" , "verdana" , sans-serif; font-size: 13.2px;">Licensor and innovator of sparsentan, the first endothelin antagonist for focal segmental glomerulosclerosis, a rare pediatric kidney disease</span><br />
<span style="background-color: white; color: #666666; font-family: "trebuchet ms" , "trebuchet" , "verdana" , sans-serif; font-size: 13.2px;">Co-Inventor of a new series of molecules for the treatment of Canavan Disease</span><br />
<span style="background-color: white; color: #666666; font-family: "trebuchet ms" , "trebuchet" , "verdana" , sans-serif; font-size: 13.2px;">Co-Inventor of a new series of molecules for the treatment of Lafora Disease</span><br />
<span style="background-color: white; color: #666666; font-family: "trebuchet ms" , "trebuchet" , "verdana" , sans-serif; font-size: 13.2px;">Inventor of a fusion protein platform for the treatment of several rare genetic disorders</span><br />
<span style="background-color: white; color: #666666; font-family: "trebuchet ms" , "trebuchet" , "verdana" , sans-serif; font-size: 13.2px;">Co-Inventor of a potential treatment for SLO Syndrome</span><br />
<span style="background-color: white; color: #666666; font-family: "trebuchet ms" , "trebuchet" , "verdana" , sans-serif; font-size: 13.2px;">Ask about me. I wish you would.</span>Pharma Skeletonshttp://www.blogger.com/profile/01448776535058222749noreply@blogger.com199tag:blogger.com,1999:blog-3565628192303069579.post-19390205474201999022018-03-29T19:23:00.000-07:002018-03-29T19:24:41.523-07:00Launching April 1<span style="font-family: Georgia, "Times New Roman", serif;"><br /></span>
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<span style="font-family: Georgia, "Times New Roman", serif;">To keep you entertained, here is some propaganda fake news BS
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<a href="http://thehill.com/policy/healthcare/380502-phrma-ads-blame-insurers-for-drug-costs"><span style="font-family: Georgia, "Times New Roman", serif;">http://thehill.com/policy/healthcare/380502-phrma-ads-blame-insurers-for-drug-costs</span></a>Pharma Skeletonshttp://www.blogger.com/profile/01448776535058222749noreply@blogger.com112